| | Employment and Health Related Services (CAEHRS) | Sheffield | £8B |
| | Personal Protective Equipment | Belfast | £5B |
| | Salford Crescent and University District Development | Salford | £2B |
| | Innovation Chain North | Manchester | £750M |
| | Medical Surgical Wholesaler | Dartford | £750M |
| | Network Connectivity and Telecommunication Solutions | Wakefield | £750M |
| | Waste Management Services | West Malling | £750M |
| | Care and Support for Adults and Young People Preparing for Adulthood Flexible Purchasing System | Liverpool | £702M |
| | Wholesaler Pharmaceutical Distribution | Birmingham | £600M |
| | Debt Resolution Services | Liverpool | £550M |
| | Integrated Community Care Equipment | West Malling | £500M |
| | Tunnel and Lineside Mechanical and Electrical Systems for Phase One and Phase 2a of the HS2… | Birmingham | £498M |
| | Products for the Treatment of Haemophilia A | Runcorn | £334M |
| | Learning and Development | Liverpool | £315M |
| | RM6145 | Liverpool | £315M |
| | High Speed Two (HS2) Ltd, Overhead Catenary System | Birmingham | £302M |
| | Overhead Catenary System for HS2 LTD | Birmingham | £302M |
| | Water Retail Services | Newcastle upon Tyne | £300M |
| | Historical Railways Estate (HRE) - Works Framework | Birmingham | £254M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £252M |
| | Responsive Repairs, Voids and Associated Works (Scotland) Dynamic Purchasing System | Edinburgh | £250M |
| | Lower Thames Crossing - Integration Partner | Bedford | £242M |
| | Print Marketplace | Liverpool | £200M |
| | Road Asset Renewal | Maidstone | £160M |
| | Advertising Solutions | Leicester | £150M |
| | Trade Law Panel | Liverpool | £115M |
| | Planned Works Framework — Kitchens, Bathrooms, Windows and Doors | Liverpool | £103M |
| | Courier Services | Wakefield | £100M |
| | Expansion of Care Home Services for People Aged 16 Upwards Framework Agreement | Nottingham | £100M |
| | Homecare Medicines Services for Immunoglobulin Therapies | Cambridge | £100M |
| | Norwich Western Link | Norwich | £100M |
| | Public Cloud Hosting Services - Service Continuity | London | £100M |
| | Supported Living Accommodation and Day Opportunities for Adults and Older People With Learning Disabilities, Physical/Sensory Impairment,… | Coventry | £92M |
| | Clinical Assessment Service for Kent, Medway & Sussex CCGs | Sittingbourne | £91M |
| | TSC Term Service Framework for Building Maintenance and Minor Building Works for Belfast Health and Social… | Belfast | £90M |
| | DPS for Domiciliary Care Services in Powys | Llandrindod Wells | £86M |
| | General Stationery and Office Paper | Edinburgh | £80M |
| | Manufacture, Overhaul and Repair of Bespoke Components | London | £75M |
| | Preliminary Market Consultation for Broadband & Telecoms for Schools | Derby | £75M |
| | FM Services (Mechanical, Electrical and Building Fabric) | London | £63M |
| | NHS England and NHS Improvement (East) - Cambridgeshire Prisons, Claire Lodge SCH and Dental Services at… | Cambridge | £62M |
| | NHS England and NHS Improvement (East) — Cambridgeshire Prisons, Claire Lodge SCH and Dental Services at… | Cambridge | £62M |
| | Exercise Books, Exercise Papers, Office Pads and Notebooks | Leicester | £58M |
| | Dynamic Purchasing System (DPS) for Social Care and CCG Funded Home Care and Outreach Support Spot… | Uxbridge | £56M |
| | Employee Benefits Including Recognition and Discounts With Salary Sacrifice Schemes (Everybody Benefits) | Northallerton | £50M |
| | Indirect Fires Simulation (IDFS) | Bristol | £50M |
| | Insurance and Associated Services for Academies and Schools | Salford | £50M |
| | Nursing Home Placements or Domiciliary Care for Patients Newly Requiring NHS Continuing Healthcare | Stoke on Trent | £50M |
| | Highways England Winter Fleet Replacement (2021 | Birmingham | £43M |
| | TSC Term Service Framework for Electrical Maintenance Work and Minor Electrical Installation Works for Belfast Health… | Belfast | £42M |