| | National Framework for Developer Led Schemes | Newcastle | £47B |
| | National Fuels (2) | Liverpool | £2B |
| | Digital and IT Professional Services (DIPS) Framework | Corsham | £1B |
| | Human Normal Immunoglobulin and Anti-D Immunoglobulin | Runcorn | £1B |
| | Major Building Works | Telford | £1B |
| | Services Related to COVID-19 | Newport | £1B |
| | Extra-Care Housing in Cornwall | Truro | £942M |
| | Home Care Including Carers Home Based Respite Services in Staffordshire | Stafford | £506M |
| | IT Hardware Including New, Remanufactured and Refurbished, Disposal and Associated Services | West Malling | £500M |
| | Human Normal Immunoglobulin and Anti-D Immunoglobulin | Runcorn | £450M |
| | Nursing and Residential Accreditation | Nottingham | £418M |
| | Minor Works Framework Agreement | Uxbridge | £400M |
| | Provision Artificial Intelligence (A.I), Imaging and Radiotherapy Equipment, Associated Products and Diagnostic Imaging | Salford | £360M |
| | Workers to Support the National Testing Programme | London | £350M |
| | Vehicles Under Short Term, Flexi and Termed Hire Framework | Widnes | £310M |
| | Water Retail Services | Newcastle upon Tyne | £300M |
| | HH Electricty MoJ — EDF | London | £260M |
| | Integrated Asset Care | Workington | £250M |
| | Intergrated Asset Care | Workington | £250M |
| | Landsolve 2.0 — For Land Advisers/Brokers | Sheffield | £250M |
| | Future Theory Test Service (FTTS) Test Centre Network (TCN) | Nottingham | £231M |
| | Passenger Transport | Taunton | £230M |
| | Street Services | Bexleyheath | £188M |
| | Construction Contractors Framework Agreement | Staines upon Thames | £187M |
| | Respiratory Therapy Equipment and Consumables | Salford | £176M |
| | Hosting and Application Support Services | London | £135M |
| | DoF Land and Property Services Landweb Extension | Belfast | £125M |
| | Waste Collection Services on Behalf of Stratford-On-Avon District Council and Warwick District Council | Warwickshire | £120M |
| | E-PCR Machines and Reagents | London | £118M |
| | NHS National Generic Pharmaceuticals Transition | Runcorn | £116M |
| | NHS National Generic Pharmaceuticals - Transition | Runcorn | £116M |
| | Dynamic Purchasing System for Transport Services | Carlisle | £100M |
| | WSCC - TH - Highways Services Contracts | West Sussex | £96M |
| | Care Provider for Nursing and Residential Care Home (Beachcroft House) | London | £78M |
| | Insurance & Associated Services for Colleges | Salford | £75M |
| | Insurance and Associated Services for Colleges | Salford | £74M |
| | Insurance & Associated Services for Colleges | Salford | £74M |
| | Lake Lothing Third Crossing Build | Suffolk | £68M |
| | Herpes Zoster (Shingles) Vaccine(recombinant, Adjuvanted) | Runcorn | £66M |
| | Radioactive Metallic Waste Treatment Services Framework | Seascale | £65M |
| | Plymouth Supported Living Framework | Plymouth | £60M |
| | Staff Absence Protection & Reimbursement Framework | Salford | £60M |
| | UWE Student Accommodation Project 3 - Building Works | Bristol | £60M |
| | Integrated Urgent Care – Call Handling, Clinical Assessment Service and GP Out of Hours | London | £59M |
| | National Framework for Office Equipment | Edinburgh | £56M |
| | VTM Filled Vials | London | £54M |
| | Health Social Care Equipment and Associated Services | Wakefield | £50M |
| | London and Quadrant Housing Trust — Supply and Fix Kitchen Units Framework 2021 | Stratford | £50M |
| | Surrey and Sussex Bluelight Accident Repair | East Sussex | £50M |
| | Surrey and Sussex Bluelight Accident Repair Framework | East Sussex | £50M |
| | Sea Water Systems Equipment Support | Bristol | £49M |
| | Human Challenge Studies | London | £46M |
| | Food to Go | Birmingham | £42M |
| | Cold Beverages, Confectionery and Snacks | Birmingham | £42M |
| | Link: 2 IT Hardware | Salford and Sheffield | £42M |
| | Vaccinations Programme: Flexible Resource Pool | Leeds | £42M |
| | Medical Gases, Cylinders, Associated Consumables and Services | Birmingham | £40M |
| | Medical Gases, Cylinders, Associated Consumables and Services Reference Number | Birmingham | £40M |
| | Solar Framework | Truro | £40M |
| | Concrete Roads - Design Framework | Bedford | £39M |
| | Concrete Roads — Design Framework | Bedford | £39M |
| | Digital Core | Nottinghamshire | £35M |
| | Dundonal International Ice Bowl New Build and Associated Works - Main Contractor Package | Lisburn | £35M |
| | Municipal Waste Transfer and Treatment | Edmonton | £35M |
| | PHE - Corporate - Marketing Contact Centre Services | Salisbury | £35M |
| | Waste Management Equipment Support | Bristol | £35M |
| | Workshops In-Service Support (WISSC) | Bristol | £33M |
| | Strategic Crime Intelligence, Security and Welfare in the Southern Region | London | £33M |
| | Northern Ireland Fire and Rescue Service - Learning and Development Centre, Cookstown | Lisburn | £31M |
| | Call Off of Framework for Print Services | Salisbury | £30M |
| | Managed Print and Digital Solutions | Salisbury | £30M |
| | Communal Entrance Doors Framework | Derbyshire | £30M |
| | CPI and RPI Local Price Collection and Associated Statistical Services | Newport | £30M |
| | HH Electricity Home Office - EDF | London | £30M |
| | Laboratory Consumables and Reagents | Birmingham | £30M |
| | PPE for the Emergency Services and Wider Public Sector | Wakefield | £30M |
| | Workforce Management System | Bicester | £30M |
| | Community Audiology Services | Oxford | £28M |
| | Prepaid Card Accounts | Newcastle upon Tyne | £24M |
| | New Building for Northern Regional College — Coleraine Campus | Belfast | £24M |
| | Surgical Type IIR Masks | Cardiff | £23M |
| | New Building for Northern Regional College - Coleraine Campus | Belfast | £22M |
| | BHCC MH Substance Misuse Service Reference Number: BHCC — | Hove | £22M |
| | Wyken Estate Regeneration | Birmingham | £21M |
| | Acquisition, Design and Build Services for Telecoms Mast Base Station Sites for the Emergency Services Mobile… | London | £20M |
| | Air Scida ( Sites Site Coordination Installation Design Authority) | High Wycombe | £20M |
| | CCTV Services | London | £20M |
| | Integrated Theatres Related Products and Services | Normanton | £20M |
| | NHS Scotland National Uniform | Edinburgh | £19M |
| | Major Works Integrated Consultant Team (ICT) Framework | Belfast | £18M |
| | Type IIR Surgical Masks | Cardiff | £18M |
| | Housing Response and Void Repairs Term 2021 | Forfar | £17M |
| | Community Audiology Services | Aylesbury | £17M |
| | Re-Roofing & Roof-Line Associated Works 2021 | Basingstoke | £15M |
| | Re-Roofing Roof-Line Associated Works 2021 | Basingstoke | £15M |
| | Professional Services Framework Agreement | Staines upon Thames | £14M |
| | ICT Framework | Glasgow | £13M |
| | ICT Framework Agreement | Glasgow | £13M |
| | Home Care Services Zone 1 | Gateshead | £13M |
| | Laboratory Testing — UK Athlete Blood and Urine Testing | London | £12M |