External Assessment Centres Framework

Including: critical appraisal of submitted evidence to support the development of NICE outputs; evidence synthesis; de novo economic modelling and critiquing and revising existing models; updating information and evidence on technologies to support guidance review; preparation of evidence summaries on new and novel technologies; systematic review and meta-analysis; market intelligence analysis; supporting identification, topic selection and scoping of medtech products, confirmations of regulatory status for medtech products.

Including: providing technical support to evaluation programmes; advanced methodological development for all types of health technologies, including pharmaceuticals, medical and diagnostic technologies and related products; providing educational support; providing advanced methodological, analytical and other ad hoc support to NICE and its independent advisory bodies on the assessment of medicines and medical technologies; providing quality assurance of economic models and other Supplier outputs; providing training on HTA and related disciplines and developing online training resources on HTA for NICE staff and committee members; evidence searching; systematic review and meta-analysis; de-novo modelling.

3a - Primary data generation and analysis Including: protocol development for promising technologies where the available evidence is insufficient to recommend routine adoption; pragmatic facilitation of collaborative research acting as the academic lead and research sponsor where needed, on clinical, laboratory, and methodological projects investigating the clinical utility of specific healthcare technologies; real-world evidence collection activities including establishing patient registries, analysing register data, and similar schemes; the specification, compilation, validation and analysis of datasets including linkage with other "real-life" data sources. This may include analysis of data protection/ information governance and preparation of paperwork as required. The Supplier may be required to manage a third party to undertake data collection and analysis, developing the contractual paperwork and holding the budget for the work as necessary. Lot 3b - Real World Evidence Generation for Managed Access Including: Managed Access evidence generation using existing registers or databases, feasibility studies, data protocol development, pilot studies; data collection and active surveillance; active data surveillance; grant applications; data linkage and complex modelling and/or analyses; register close down; journal publications

Lot 4a - Clinical and Economic Evidence Assessment - additional capacity Including: critical appraisal of submitted evidence to support the development of NICE outputs; evidence synthesis; de novo economic modelling and critiquing and revising existing models; updating information and evidence on technologies to support guidance review; preparation of evidence summaries on new and novel technologies; systematic review and meta-analysis; market intelligence analysis; supporting identification, topic selection and scoping of medtech products, confirmations of regulatory status for medtech products. Lot 4b - Decision and methodological support services - additional capacity Including: providing technical support to evaluation programmes; advanced methodological development for all types of health technologies, including pharmaceuticals, medical and diagnostic technologies and related products; providing educational support; providing advanced methodological, analytical and other ad hoc support to NICE and its independent advisory bodies on the assessment of medicines and medical technologies; providing quality assurance of economic models and other Supplier outputs; providing training on HTA and related disciplines and developing online training resources on HTA for NICE staff and committee members; evidence searching; systematic review and meta-analysis; de-novo modelling. Lot 4c - Supplementary services - Research & ethics Including: advice on research governance and ethics support including access to a research ethics committee. Lot 4d - Supplementary services - Technical assessment Including: technical assessment to inform on effective use. The following sections list the general approach NICE takes to the work carried out by the EACs, followed by details of work packages issued under each Lot and specific details of the modules of work generally included in standard work packages.