Provision of a Multiplex Fluorescence Scanner with quantitative pathology imaging and analysis

Concepts

• precision equipment
• akoya biosciences
• provision of a multiplex fluorescence scanner
• quantitative pathology imaging
• quantitative multiplex image analysis
• purchase of a multiplex fluorescence slide scanner
• analysis
• advance image analysis
• pathology
• pathology component

Location

United Kingdom:

Description

Award to Akoya Biosciences for the purchase of a multiplex fluorescence slide scanner with quantitative pathology imaging and analysis to be used in the Research Department, Porton.

Total Quantity or Scope

The provision of a Multiplex Fluorescence Scanner will enable UK HSA to produce quantitative multiplex image analysis, with elements of the application of artificial intelligence in pathology (advance image analysis, such as tissue classification, phenotyping or pattern recognition) to be applied to ongoing and future research projects focusing on high priority activities including COVID19, Ebola, Zika, Crimean Congo Haemorrhagic Fever, Chikungunya, Zika virus infection, Q Fever, Anthrax, Tuberculosis, Monkeypox, Influenza, Pertussis, Meningococcal disease, Anti-Microbial Resistance, etc.The Research team is responding to the COVID19 outbreak by delivering the pathology component of every pre-clinical experiment carried out at Porton, including vaccines and therapeutics against SARS-CoV-2. This work is supporting the UKHSA Infectious Disease Strategy, in the development of interventions against disease, and particularly at the moment support our strategy of being ready to respond to Pandemics as part of the current international global response.

Award Detail

Award Criteria

CPV Codes

• 38000000 - Laboratory, optical and precision equipments (excl. glasses)

Legal Justification

UK HSA is responding to the COVID19 outbreak by delivering the pathology component of every pre-clinical experiment carried out at PHE Porton, including vaccines and therapeutics against SARS-CoV-2. The proposed equipment will provide resilience, increased output and objective image analysis (high throughput) of multiple samples, increasing the power of special pathology techniques (FISH and fluorescence immunolabelling) to study the pathogenesis and immune responses in the animal studies of SRAS-CoV-2 infection, also applicable to all the other pathogens.Akoya is the only provider of automated tools and algorithms for the determination of library spectra for the quantitative elimination of autofluorescence and the determination of pure biomarker spectra from unmixed spectra taken from tissue specimens.The Vectra Polaris Automated Quantitative Pathology Imaging System will digitalise multiplex-stained slides increasing resilience as it would be able to scan conventional brightfield stained slides (in case our current histology scanner is out of order for any reason) and will be able to produce digital H&E e-slides from fluorescence-stained slides, reducing the workload in the laboratory. At present, PHE does not have the capacity or resources of reading and scanning multiplex-stained slides and need to produce single-stained slide for a variety of markers with a considerable amount of time and resources associated.The technology within Polaris as well as some of the proprietary software that runs it was all developed in house and patented. Its unique capabilities via the multispectral technology set the Polaris apart for quantitative biomarker analysis and detailed phenotyping of researchers tissue samples.

Other Information

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