Cloud Infrastructure, Trusted Research Environment, and Researcher Billing Contract

Our Future Health aims to procure secure and scalable public cloud infrastructure to support a health research programme. The selected supplier will be one of our most important technology partners as we build and scale our systems. The cloud infrastructure will underpin web sites and apps used by our participants, a data store and data processing systems, a trusted research environment (TRE) and associated systems used by researchers from around the world, and underlying systems to operate and monitor the programme. The selected supplier will provide UK hosting for secure public cloud infrastructure with a comprehensive set of standard compute, storage and infrastructure services. We are interested to work with cloud providers that have good availability of TRE providers already working within their systems. Estimated value excluding VAT: between £3m and £6.5m over 3 years; £20m over 5 years We expect costs to increase as participant numbers increase. Total projected costs during years 1-3 of the contractual arrangement would be between £3m and £6.5m and over 5 years we expect a range of £9m - £21m. We will not be able to predict a narrower range until we have more clarity during 2022 about which services will be hosted in our cloud and which with suppliers, as well as more detailed technical and data architecture that will happen following this procurement. Note that these costs include only Our Future Health usage of our cloud, not that of the researchers using the TRE billed separated by the Lot 3 supplier. The total cloud expenditure will therefore be considerably greater than the value of our contract. Additional information: To respond to this opportunity please email ourfuturehealth@curshaw.com stating in the subject line that this tender relates to Lot 1

Our Future Health is planning to procure a trusted research environment (TRE) to enable registered researchers to access and use data within a single secure environment to conduct approved research studies. The success of Our Future Health rests on the research that is done with the data and the cohort, together with our commitment to robust security, strict governance and participant confidentiality. A TRE is an environment, that may be cloud-based, that allows registered researchers working on an approved study to conduct analysis on de-identified or pseudonymised datasets in a secure manner, where export of results data is permitted but exports of individual level data is not permitted. It is expected that a TRE will create a separate partitioned workspace for each approved study, allow registered researchers to use a variety of common tools for data science, analysis, and research (including large-scale genomic analysis), to upload additional tools and datasets subject to the security restrictions of the environment, to have flexibility in their use of compute and storage resources. A TRE should maintain the access control and secure boundary to prevent unauthorised access to or download of data, and to maintain auditable access and usage logs. The selected TRE (lot 2) will be expected to run on the selected cloud infrastructure (lot 1), with the selected provider of researcher billing (lot 3) providing services to manage the cost and billing of cloud usage by researchers in the TRE. We hope to have a beta version of a TRE tested and launched by the end of Q3 2022, and a full version tested and launched by the end of Q4 2022. Estimated value excluding VAT: between £2m and £3.15m over 3 years; between £3m and £4.75m over 5 years We are assuming that set-up costs will range between £0.5 and £1m. Any separately charged set-up will be milestone driven and payable on the successful completion of the key steps in the implementation and integration. Total committed costs therefore including set-up and years 1-3 of the contractual arrangement would therefore be between £2m and £3.15m. Costs for years 4-5 are expected to be in the range of £1.0m to £1.6m, driving a total contract value between £3m and £4.75m. Additional information: To respond to this opportunity please email ourfuturehealth@curshaw.com stating in the subject line that this tender relates to Lot 2

In order to provide a scalable and flexible service, where researchers can use the cloud resources that they need, we anticipate a system where researchers pay for their own cloud storage and compute within their TRE workspace. We are therefore planning to procure a partner who can meet the following requirements, working together with the selected provider of public cloud infrastructure (lot 1) or the selected TRE (lot 2): - Billing of researchers and collection of payments to be handled by a supplier or partner, not by Our Future Health. - Our Future Health shall not be liable for the costs of researchers' compute and storage within the TRE. - Our Future Health shall not incur data transfer charges between the primary data store and the TRE. - Cloud pricing shall be uniform for both Our Future Health's usage and researcher usage. Bidders cannot bid for Lot 3 alone and must bid for both or either Lot 1 and/or Lot 2. Additional information: To respond to this opportunity please email ourfuturehealth@curshaw.com stating in the subject line that this tender relates to Lot 3