Patchliner automated ePhys patch-clamping system

A Contract Award Notice
by CARDIFF UNIVERSITY

Source: Find a Tender
Type: Contract (Supply)
Duration: not specified
Value: 244K

Sector: HEALTH
Published: 16 May 2022
Delivery: not specified
Deadline: n/a

Concepts

Location

Cardiff

Geochart for 2 buyers and 1 suppliers

2 buyers

Cardiff University Cardiff

1 supplier

Nanion Technologies Muenchen

Description

Patchliner automated ePhys patch-clamping system for characterisation of cell surface and intracellular ion channels

Award Detail

1	Nanion Technologies (Muenchen) Reference: cu.359.sf Num offers: 1 Value: £244,100

Award Criteria

PRICE

CPV Codes

33110000 - Imaging equipment for medical, dental and veterinary use

Indicators

Award on basis of price.

Legal Justification

The Patchliner is a fully automated planar patch-clamping system with unparalleled versatility, compared to rival automated systems, and ease-of-use compared to conventional patch-clamping, which requires several months specialist training. This ease-of-use is the key attribute, as high quality electrophysiology data can be generated after just one training session, making the equipment realistically multi-user and allowing PhD or undergraduate students to perform otherwise complex ion channel electrophysiological recordings. The equipment will allow basic research into ion channel function, such as ion permeability, voltage dependency, and the effects of ligands and modulators on these, and ion channel directed drug discovery, by researchers who are not expert electrophysiologists. Planar patch-clamping systems utilise borosilicate glass chips with a micron size aperture, embedded in a microfluidic chamber, to take the place of pipettes in a conventional patch-clamping set up. Negative pressure attracts cells to the aperture, where a reliable seal is formed automatically with the cell, allowing recording of ion flux. We will use this equipment for 1) ion channel targeted drug discovery, 2) characterisation of differentiated stem cell models (e.g. neurons, cardiomyocytes), 3) phenotypic characterisation of ion channels, 4) characterisation of pore-forming toxin ion permeability, 5) ion flux in plant cells and 6) the impact of biomaterials and artificial amino acids on ion channel function.