Supply of a Biophysical Equipment System

Concepts

• precision equipment
• markinch
• center for targeted protein degradation
• laboratory and optical equipment
• supply of a biophysical equipment system
• molecular glue biophysics
• biophysical characterization
• additional biophysical parameters
• ternary complex formations
• tender aims

Location

Description

Biophysical characterization of binary and ternary complex formations in proximity-inducing compounds is a key step in the iterative improvement of potency of Proteolysis Targeting Chimeras (PROTACs) and molecular glues. In order for us to have the ability to scrutinise the affinity and kinetics of binary and ternary complexes with challenging sample requirements (e.g. low affinity (1-10 uM) complexes, low protein availability, homoPROTACs etc) highly specialised systems are required. The technique will provide a readout of compound/PROTAC affinity while providing insight into additional biophysical parameters, all of which can be critical for compound optimization/prioritization. This tender aims to substantially increase the ability of biophysicists and chemists to assess PROTAC/molecular glue biophysics and will be complimentary to techniques currently available to the new Center for Targeted Protein Degradation (CeTPD) (including SPR, ITC, TR-FRET) while being able to probe interactions that other techniques cannot currently scrutinise. The new machine will be housed in the CeTPD.

Renewal Options

Extended warranty/service if taken out later and not at time of equipment purchase.

CPV Codes

• 38000000 - Laboratory, optical and precision equipments (excl. glasses)

Indicators

• This is a one-off contract (no recurrence)
• Renewals are available.
• Professional qualifications are sought.

Other Information

** PREVIEW NOTICE, please check Find a Tender for full details. ** NOTE: To register your interest in this notice and obtain any additional information please visit the Public Contracts Scotland Web Site at https://www.publiccontractsscotland.gov.uk/Search/Search_Switch.aspx?ID=698752. The buyer has indicated that it will accept electronic responses to this notice via the Postbox facility. A user guide is available at https://www.publiccontractsscotland.gov.uk/sitehelp/help_guides.aspx. Suppliers are advised to allow adequate time for uploading documents and to dispatch the electronic response well in advance of the closing time to avoid any last minute problems. (SC Ref:698752) Download the ESPD document here: https://www.publiccontractsscotland.gov.uk/ESPD/ESPD_Download.aspx?id=698752