DMS INTEND TO AWARD RESEARCH INTO A RANDOMISED CONTROLLED TRIAL OF VOLATILE ANAESTHETIC AGENTS WITH INTRAVENOUS SEDATION IN TRAUMATIC BRAIN INJURY (TBI)

Concepts

• research laboratory
• lichfield
• uhnm
• clinical trial
• clinical trials
• intravenous sedation
• research
• dms
• research services
• randomised controlled trial of volatile anaesthetic agents

Location

United Kingdom: Royal Stoke University Hospital

Description

Defence Medical Services intend to award the Intravenous Sedation in Traumatic Brain Injury Contract, otherwise known as TBI, single source contract with an NHS University Teaching Hospital (UHNM). This is required for completion of PHD study as the student is based in this specific site and cannot conduct this research at another site. The trust will be contracted to provide supervision and facilities that will enable the student to conduct the PhD (research) study.

Total Quantity or Scope

The requirement is part of an ongoing four-year PhD study, the military student is conducting a clinical trial with University Hospitals of North Midlands (UHNM), which also forms part of his military clinician duties. These clinical trials will be conducted in years two and three of the PhD. The PhD was endorsed and began in September 22. His PhD is being undertaken with Staffordshire University which is also conveniently placed for the student to maintain both his clinician skills and receive the appropriate academic support. Additional information: The Authority will proceed to enact the single source procedure and engage with the UHNM. Institutions are welcome to enquire by emailing Luke.morgan143@mod.gov.uk this VTN will remain open for 30 calendar days.

Award Detail

Award Criteria

CPV Codes

• 73111000 - Research laboratory services
• 71900000 - Laboratory services
• 73110000 - Research services

Legal Justification

Defence Medical Services intend to award the Intravenous Sedation in Traumatic Brain Injury Contract, otherwise known as TBI, single source contract with an NHS University Teaching Hospital (UHNM). This is required for completion of PHD study as the student is based in this specific site and cannot conduct this research at another site. The student cannot complete there study outside of the university, nor have they expressed any interest to do so, as this would cancel the progress made towards there PhD.

Other Information

** PREVIEW NOTICE, please check Find a Tender for full details. ** It is considered that this contract can be placed using the single source procedure without prior publication of a contract notice as permitted by Regulation 14 of the Public Contract Regulations 2015, exempting public sector Contracts for research and development services. Volatile anaesthetic agents are already widely used in human practice, including for anaesthesia for patients with brain injury requiring neurosurgery. They may reduce the activity of a known pathway of abnormal brain cell death and therefore have a neuroprotective effect. There have been no randomised controlled trials comparing volatile anaesthetic sedation against standard intravenous sedation for Traumatic Brain Injury (TBI) requiring critical care. Therefore, this study will be the first randomised controlled trial examining a novel neuroprotective strategy involving agents which are already widely available and in use in human medicine. If a benefit is shown and use of an inhaled sedation technique reduces mortality or morbidity from severe TBI, then this will be a clear clinical benefit to service personnel at risk of suffering from a TBI, and from a wider Defence perspective, if effective as a strategy to reduce the severity of traumatic brain injury, this will reduce the burden of death from TBI on operations or exercises, and the rehabilitation requirement and loss of troops to downgrading and medical discharge as the result of severe TBI.