Term Framework for the Provision of Chemistry Synthesis and other Chemistry Services Outsourcing Framework

Concepts

• research services
• dundee
• other chemistry services outsourcing framework
• other chemistry services
• other chemistry services outsourcing
• chemistry services outsourcing framework
• chemistry synthesis
• chemistry services
• chemistry support
• array chemistry

Location

Biological Chemistry & Drug Discovery (BCDD), University of Dundee

Description

Second-Generation Framework for the provision of Chemistry Synthesis and other Chemistry Services Outsourcing with initial term of two (2) years with the option to extend for up to 2 x 12 months, if required, at the sole discretion of the University and subject to ongoing satisfactory performance by the appointed Service Providers. The Services will include: 1. FTE rate for provision of chemistry support for medicinal chemistry programme(s), typically making 50mg samples of compounds for initial biological evaluation. For actives, re-synthesis on a larger scale may be required (typically 0.5g to 5g scale). The ability to carry out array chemistry is important; 2.Bespoke piece(s) of chemistry e.g. synthesis of a defined list of compounds, typically at <50mg scale; 3. Scale up of chemistry, up to 200g; 4.Chiral separation by crystallization or SFC/Chiral HPLC on (up to) gram scale. 5.Synthesis of intermediates at 5-100g; For all of these, a purity level will be defined. This will depend on the phase of the project, but typically is >95% purity and for scale up> 98% purity with no impurity >0.5%; 6. Experimental write-ups, when requested, including compound characterization by 1H NMR, 13C NMR and LCMS or UPLC/MS for publications, in-vivo release, tech-transfer to DDU or other CRO for patent purposes.

Total Quantity or Scope

This Second-Generation Framework is required to provide a quick route to market for the provision of Chemistry Synthesis and other Chemistry Services. The initial contract term will be two (2) years, with the option to extend for 2 x 12 months, if required, at the sole discretion of BCDD and subject to ongoing satisfactory performance by the appointed Service Providers The Chemistry Synthesis and Other Chemistry Services required will include: … 2. Bespoke piece(s) of chemistry e.g. synthesis of a defined list of compounds, typically at <50mg scale; -Scale up of chemistry, up to 200g; -Chiral separation by crystallization or SFC/Chiral HPLC on (up to) gram scale. -Synthesis of intermediates at 5-100g; … -Experimental write-ups, when requested, including compound characterization by 1H NMR, 13C NMR and LCMS or UPLC/MS for publications, in-vivo release, tech-transfer to DDU or other CRO for patent purposes. The subsequent route to market will be via Mini Comp under the Framework.

Renewal Options

Option to extend Framework for maximum 2 x further years, subject to ongoing need and satisfactory performance by the appointed service providers.

Award Criteria

CPV Codes

• 73110000 - Research services

Indicators

• Bids should cover the whole contract.
• Renewals are available.
• Professional qualifications are sought.
• Staff qualifications are relevant.
• Award on basis of price.

Other Information

NOTE: To register your interest in this notice and obtain any additional information please visit the Public Contracts Scotland Web Site at https://www.publiccontractsscotland.gov.uk/Search/Search_Switch.aspx?ID=761553. The buyer has indicated that it will accept electronic responses to this notice via the Postbox facility. A user guide is available at https://www.publiccontractsscotland.gov.uk/sitehelp/help_guides.aspx. Suppliers are advised to allow adequate time for uploading documents and to dispatch the electronic response well in advance of the closing time to avoid any last minute problems. (SC Ref:761553) Download the ESPD document here: https://www.publiccontractsscotland.gov.uk/ESPD/ESPD_Download.aspx?id=761553