Supply of Recombinant Proteins to APHA

Concepts

• peptones and protein substances
• apha
• recombinant proteins
• recombinant
• proteins
• purification
• plant health agency
• cloning
• a polyhistidine tags
• the animal and plant health agency

Location

APHA, Weybridge

Description

Supply of Recombinant Proteins to the Animal and Plant Health Agency (APHA).

Total Quantity or Scope

The requirement is for production and supply of nine (9) novel recombinant proteins in a polyhistidine tags ("His-tags") presentation (to include cloning, expression and purification).

Award Detail

Award Criteria

CPV Codes

• 24956000 - Peptones and protein substances

Indicators

• Award on basis of price.

Legal Justification

This product is required purely for research purposes. This procurement aims to provide a small quantity of the final products (recombinant proteins, 2mg/ml in a purified state) that can be used to validate previously generated data and allow further development of serological assays. An analysis of the five requirements of the Frascati guidelines have been completed and all five criteria are met for this requirement:- Novel: These required products are novel proteins that have not been previously produced or made available commercially. - Creative: Fragments identified in the discovery phase have been identified for production as full chain recombinant proteins. This is the first time these have been identified for any species.- Uncertainty of outcome: Due to the novel nature of the requirement, there is a possibility that the Supplier will not be able to produce one / more of these proteins. The production of the proteins will be challenging as there may be unknown factors that could cause the proteins to be unstable.- Systematic: The project is conducted under quality standard ISO 90001:2015. This standard requires documentation of all work, including obtaining data sheets of the procured proteins. - Transferrable: Knowledge will be fully transferable in the future and would allow an alternative supplier to re-produce the results.