Term Framework for the Provision of Chemistry Synthesis and other Chemistry Services Outsourcing Framework

Concepts

• research services
• dundee
• other chemistry services outsourcing framework
• other chemistry services
• other chemistry services outsourcing
• chemistry services outsourcing framework
• chemistry synthesis
• chemistry services
• chemistry support
• array chemistry

Location

Biological Chemistry & Drug Discovery (BCDD), University of Dundee

Description

Second-Generation Framework for the provision of Chemistry Synthesis and other Chemistry Services Outsourcing with initial term of two (2) years with the option to extend for up to 2 x 12 months, if required, at the sole discretion of the University and subject to ongoing satisfactory performance by the appointed Service Providers. The Services will include: 1. FTE rate for provision of chemistry support for medicinal chemistry programme(s), typically making 50mg samples of compounds for initial biological evaluation. For actives, re-synthesis on a larger scale may be required (typically 0.5g to 5g scale). The ability to carry out array chemistry is important; 2.Bespoke piece(s) of chemistry e.g. synthesis of a defined list of compounds, typically at <50mg scale; 3. Scale up of chemistry, up to 200g; 4.Chiral separation by crystallization or SFC/Chiral HPLC on (up to) gram scale. 5.Synthesis of intermediates at 5-100g; For all of these, a purity level will be defined. This will depend on the phase of the project, but typically is >95% purity and for scale up> 98% purity with no impurity >0.5%; 6. Experimental write-ups, when requested, including compound characterization by 1H NMR, 13C NMR and LCMS or UPLC/MS for publications, in-vivo release, tech-transfer to DDU or other CRO for patent purposes.

Total Quantity or Scope

This Second-Generation Framework is required to provide a quick route to market for the provision of Chemistry Synthesis and other Chemistry Services. The initial contract term will be two (2) years, with the option to extend for 2 x 12 months, if required, at the sole discretion of BCDD and subject to ongoing satisfactory performance by the appointed Service Providers The Chemistry Synthesis and Other Chemistry Services required will include: … 2. Bespoke piece(s) of chemistry e.g. synthesis of a defined list of compounds, typically at <50mg scale; -Scale up of chemistry, up to 200g; -Chiral separation by crystallization or SFC/Chiral HPLC on (up to) gram scale. -Synthesis of intermediates at 5-100g; … -Experimental write-ups, when requested, including compound characterization by 1H NMR, 13C NMR and LCMS or UPLC/MS for publications, in-vivo release, tech-transfer to DDU or other CRO for patent purposes. The subsequent route to market will be via Mini Comp under the Framework.

Award Detail

Award Criteria

CPV Codes

• 73110000 - Research services

Indicators

Other Information

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