| | Lateral Flow - Dynamic Purchasing System (DPS) | London | £8B |
| | CHIC Merchant Services DPS | Birmingham | £2B |
| | Land, Design and Build -Derry, North and West Belfast | Belfast | £2B |
| | Voucher Schemes | Liverpool | £2B |
| | Highways Maintenance, Improvements, and Street Lighting | Sutton | £1B |
| | Southern Construction Framework (SCF) Residential Delivery and Development Framework | Exeter | £1B |
| | AASC - Asylum Accommodation & Support Services NW | London | £1B |
| | AASC - Asylum Accommodation & Support Services MEE | London | £1B |
| | Cambridgeshire County Council Highway Services | Cambridge | £900M |
| | AASC - Asylum Accommodation & Support Services NEYH | London | £821M |
| | AASC - Asylum Accommodation & Support Services South | London | £662M |
| | Pegasus — Infrastructure Services — Selection Questionnaire (SQ) — Competitive Process With Negotiation (CPN) | London | £600M |
| | AASC - Asylum Accommodation & Support Services Scotland | London | £514M |
| | Statutory Homeless Supported Temporary Accommodation in Salford | Swinton | £500M |
| | NHS Framework, North of England, Branded Medicines — Tranche A and Annual Tranche | Runcorn | £481M |
| | Older Adults Residential and Nursing Care Services | Carlisle | £450M |
| | Tower — Surgical Instruments Framework | London | £400M |
| | Traineeships Reforms and Expansion Programme | Coventry | £380M |
| | Application for a Care Home | St Austell | £355M |
| | Supported Living Framework | Chelmsford | £345M |
| | AASC - Asylum Accommodation & Support Services Wales | London | £334M |
| | City of London Markets Co-Location Programme - Main Contractor | London | £330M |
| | Scape National Consultancy Framework — Scotland | Edinburgh | £300M |
| | National Roll-Out of the Early Career Framework | London | £250M |
| | Multi Temperature Food Solutions | London | £240M |
| | AIRE - Advice Issue Reporting and Elligibility | London | £235M |
| | Mole Valley District Council - Joint-Venture Development Partner for Swan Centre and Bull Hill, Leatherhead | Dorking | £200M |
| | Free School Meals Vouchers | London | £190M |
| | Responsive Maintenance, Void Property Works and Minor Planned Works | London | £183M |
| | Kent and Medway Adult Psychological Therapies Service (Also Known as IAPT) | Ashford | £145M |
| | Home Care for Leicestershire | Leicester | £125M |
| | E-PCR Machines and Reagents | London | £118M |
| | AASC - Asylum Accommodation & Support Services NI | London | £113M |
| | Responsive Repairs, Voids, Aids and Adaptations and Planned Maintenance Works | Belfast | £108M |
| | Residential Care | Doncaster | £100M |
| | Supply, Installation and Maintenance of Low Carbon Electrical Micro-Generation | Wakefield | £100M |
| | NHSScotland Frameworks Scotland 3 | Edinburgh | £100M |
| | Somalia Stability Fund II | East Kilbride | £99M |
| | Hope Valley Capacity | London | £81M |
| | Adult Secondary Mental Health Services in West Essex | Epping | £80M |
| | Adults Secondary Mental Health Services in West Essex | Epping | £80M |
| | Interim London Clinical Services Agreement | London | £80M |
| | Commitment Agreement | London | £71M |
| | Herpes Zoster (Shingles) Vaccine (Recombinant, Adjuvanted) | London | £66M |
| | HS2 LTD Engineering Management System (EMS) | Birmingham | £65M |
| | Minor Works Contractor Framework | Leeds | £60M |
| | Surge (With Variations 1-4) | London | £59M |
| | Strategic Process Chemicals | Warrington | £58M |
| | RM&C/2021/TMAT/321 | Grimsby | £56M |
| | Covid-19 Test Digital Platform | Leeds | £51M |
| | London Borough of Havering - 5 Year Estate Improvements Programme | Preston | £50M |
| | Personal Protective Equipment | Paisley | £50M |
| | Social Housing Emerging Disruptors Framework | Warrington | £50M |
| | NRW Next Generation Construction Services 2020 | Cardiff | £49M |
| | Dermatology Services | Cambridge | £48M |
| | Core Drugs and Alcohol Treatment Service | London | £46M |
| | Respiratory Protective Equipment, Associated Equipment and Services | Exeter | £46M |
| | Commercial Works DPS | Shipley | £45M |
| | Financial Audit and Assurance Services | Victoria | £40M |
| | Laboratory Testing Services | London | £38M |
| | Total Cleaning Service Solutions | Leicester | £38M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £36M |
| | Supported Living Services in Buckinghamshire | Aylesbury | £35M |
| | Project Hire of Specialist Trailers | London | £35M |
| | Yorkshire Housing Association - Clerks of Works for Rastrick Site | Preston | £34M |
| | Pipes Fittings | Reading | £34M |
| | Repairs and Maintenance Services to Northwards Housing Managed Stock and Leasehold Properties and New Adaptations Across… | Manchester | £33M |
| | Deloitte NTP Phase 1 | London | £33M |
| | Supported Transport Dynamic Purchasing Solution (DPS) | Oxford | £33M |
| | Education & Office Furniture | Paisley | £32M |
| | The Supply of DHSC MTUs | London | £32M |
| | Control and Restraint Equipment for the Emergency Services and Wider Public Sector | Wakefield | £30M |
| | Digital Resource Pool Framework | London | £30M |
| | Laboratory Consumables | Swindon | £30M |
| | PIN for the Mobile Infrastructure Monitoring Category Strategy | London | £30M |
| | Strategic Partnership for Technical Services Framework | Wadebridge | £30M |
| | T842 Understanding Society 2020 To | Colchester | £28M |
| | Pixash Consolidated Waste and Recycling Transfer Depot - Contractor | Bath | £28M |
| | Ground Based Surveillance Radar (GBSR) | Bristol | £25M |
| | Integrated Community Equipment Services | Sandbach | £25M |
| | Rotherham Sexual Health Services - All Ages | Rotherham | £25M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £23M |
| | Call Off the Construction of Multi-Storey Car Park, Gateshead Under Scape Procure National Construction Framework (Lot… | Gateshead | £23M |
| | End User Computing and Servers | Bradford | £23M |
| | East Lothian Kerbside Waste Collection | Haddington | £23M |
| | Improving Access to Psychological Therapies (IAPT) for West Essex | Epping | £22M |
| | Storage, Warehousing and Distribution of Non-Vaccine Consumables, PPE and Equipment | Leeds | £22M |
| | Training and Support to Young People (16-19) Through Partner Organisations | Truro | £21M |
| | Asbestos ACM Removals and Associated Services and Associated Works | Yeovil | £20M |
| | Resource Services Support Framework Agreement | Belfast | £20M |
| | Stationery and Copier Paper | Caerphilly | £20M |
| | MTU Diesel Generator Support (For | Bristol | £19M |
| | Construction of Bingham Leisure Centre and Offices | Melton Mowbray | £18M |
| | Publication Printing and Fulfilment Services for the UKHO | Taunton | £18M |
| | Design and Installation of Event Duration Monitors and Flow Monitoring at Thames Water's Sewage Treatment Works… | Reading | £18M |
| | Reagents for Extraction and Testing for COVID-19 Virus | Cardiff | £18M |
| | Yorkshire Housing Association — Moor Lane, Menston — New Build | Preston | £18M |
| | SMS Provider for GOV.UK Notify | London | £18M |
| | Medical Gases — Lot 1 Medical Gases in Cylinders [2638195] | Belfast | £17M |
| | NHS England and NHS Improvement South (South East) - Integrated Health and Emotional Wellbeing Service to… | Bristol | £17M |