| | NHS England ICF Framework - NHS Increasing Capacity Framework Reference Number | Leeds | £10B |
| | Transport Technology and Associated Services | Liverpool | £2B |
| | Civil Engineering and Infrastructure Framework - England, Northern Ireland and Wales | Nottingham | £2B |
| | Scape Regional Construction Framework | Nottingham | £1B |
| | NHS Framework Agreement, Branded Medicines for London and South of England and Bevacizumab for North of… | Runcorn | £1B |
| | Project Reach | London | £1B |
| | Private Investment Construction ('PIC') Framework | Yeovil | £800M |
| | Servers Storage Solutions National Agreement | Reading | £600M |
| | Pharmacy Homecare Services - Low and Mid Tech | Exeter | £521M |
| | Pharmaceutical Services Framework Agreement | Sheffield | £500M |
| | NHS Framework Agreement, Branded Medicines for London and South of England and Bevacizumab for North of… | Runcorn | £442M |
| | Multifunctional Devices and Digital Transformation Solutions Framework | Salford | £440M |
| | Civil Engineering and Infrastructure Works Framework | Sunderland | £400M |
| | Science Engineering Delivery Framework | London | £400M |
| | DHSC Assisted Testing Framework | London | £387M |
| | DHSC International Freight and Logistics Solutions | London | £382M |
| | Books, E-Books, Standing Orders and Related Material — Joint Consortia Framework Agreement | Reading | £360M |
| | Books, E-Books, Standing Orders and Related Materials — Joint Consortia Framework Agreement | Reading | £360M |
| | Supported Living Framework Reopening1 | Chelmsford | £345M |
| | Media Buying Services | Liverpool | £320M |
| | Property Repairs & Maintenance | Dartford | £320M |
| | GMCA 267a GM One Network | Manchester | £300M |
| | Landmark Court (From TfL Property Partnerships Framework - TfL | London | £255M |
| | Archaeology Framework | Bedford | £250M |
| | AIRE - Advice Issue Reporting and Elligibility | London | £235M |
| | Multifunctional Devices and Digital Transformation Solutions Framework | Salford | £230M |
| | Integrated Urgent Care Services | Hampshire and Iow | £171M |
| | Services Agreement | London | £169M |
| | Liquid Fuels | Newcastle upon Tyne | £160M |
| | Regulated Homecare Services: For Providers in Somerset | Taunton | £155M |
| | Temporary Accommodation Dynamic Purchasing System | London | £140M |
| | Lateral Flow Testing - Second Call-Off | London | £137M |
| | Lateral Flow Testing - First Call-Off | London | £137M |
| | PPE Framework | Cardiff | £120M |
| | HS2 Old Oak Common Station - Box Piling and Diaphragm Wall | Watford | £100M |
| | Intravenous Cannula and Associated Products | London | £100M |
| | Mass Spectrometry and Chromatography Equipment | Stirling | £100M |
| | PfH Scotland EESSH Framework | Edinburgh | £100M |
| | Residential Redevelopment of the NWCC Site, South Kilburn | Wembley | £100M |
| | DHSC International Freight and Logistics Solutions | London | £96M |
| | Air, Ferry, International Rail Booking Services | London | £92M |
| | Lateral Flow Testing - First Call-Off | London | £92M |
| | Derby & Nottingham Highways Framework 2017-2021 | Nottingham | £90M |
| | FSA Delivered Official Controls in England and Wales Variation 11 | York | £87M |
| | Furniture | Durham | £85M |
| | NEPO411 Furniture | Durham | £85M |
| | Electric Vehicle Charging Infrastructure | Paisley | £80M |
| | Leisure Operating | Derby | £80M |
| | Metered Electricity | Belfast | £80M |
| | Modern Apprenticeships 2021-22 — Training Provider and Employer | Glasgow | £80M |
| | Estuary Housing Association - Repairs, Voids, Planned, Door Entry, Gas, Electrical | Southend on Sea | £76M |
| | London Highways Alliance | Wembley | £76M |
| | Medical Gases in Cylinders and Bulk Gases | Salford | £70M |
| | IUPC Laboratory Gases and Associated Equipment Framework | Reading | £67M |
| | Home Group Development Contractors Dynamic Purchasing System Cumbria | Newcastle upon Tyne | £62M |
| | Agency Staffing Project | Kingston upon Thames | £60M |
| | Building Construction Consultancy | Paisley | £60M |
| | Learning Disability Open for Providers in Somerset | Taunton | £60M |
| | Records Information Management, Digital Solutions and Associated Services | Liverpool | £60M |
| | Records Information Management, Digital Solutions & Associated Services | Liverpool | £60M |
| | Construction Work 2017 | Wigan | £57M |
| | Electronic Patient Records | Exeter | £57M |
| | Placement of Children and Young People With Independent Fostering Agencies - 4th Anniversary Re-Opening | Southampton | £55M |
| | Placement of Children and Young People With Independent Fostering Agencies — Fourth Anniversary Re-Opening | Southampton | £55M |
| | Print and Digital Communication Solutions Framework | Warrington | £55M |
| | Marine Rotating Electrical Machinery | Bristol | £55M |
| | On-Site Decontamination Service and Medical Device Management | Staffordshire | £54M |
| | DIT Foreign Direct Investment Services | London | £50M |
| | Joint Venture Residential Development With Darlington Borough Council - P2017/1190/NE | Darlington | £50M |
| | Public Cloud Compute Storage and Ancillary Services | London | £50M |
| | Royal Wolverhampton NHS Trust Main Contractor Framework Refurb D2 £10-£50million | Wolverhampton | £50M |
| | Royal Wolverhampton NHS Trust Main Contractor New Build D1 £10-£50million | Wolverhampton | £50M |
| | Flaxyard & Peckham Library Square - Design and Build | London | £46M |
| | Accommodation and Support for 16+ Older Looked After Young People and Care Leavers | Chichester | £45M |
| | Placement of Children and Young People With Independent Fostering Agencies - Fourth Anniversary Re-Opening | Southampton | £44M |
| | BCP Treatment System - Adults and Young People | Bournemouth | £42M |
| | Aseptically Prepared Cytotoxic Medicines and Monoclonal Antibodies - North of England Of | Runcorn | £41M |
| | Home Group Development Contractors Dynamic Purchasing System Cumbria | Newcastle upon Tyne | £40M |
| | Kingsbrook Secondary School - Principal Contractor | Aylesbury | £37M |
| | Seafox CFVTN | Bristol | £36M |
| | Seafox Follow on Support | Bristol | £36M |
| | Desktop Devices & Hardware Services | Hatfield | £35M |
| | Edwards Court Extra Care Scheme | Exeter | £35M |
| | Lateral Flow Testing - First Call-Off | London | £34M |
| | Deloitte NTP Phase 1 | London | £33M |
| | Engineering Delivery Framework | London | £32M |
| | Adult Influenza Vaccines - Secondary Care | Runcorn | £29M |
| | Integrated Public Health Nursing Service (0-19 IPHNS) | Rotherham | £29M |
| | Skills Training in the Food Sector — DPS for Skills Providers and Training Provision, Skills for… | Chester | £27M |
| | Emergency and Repatriation Travel Management Services for FCDO | Liverpool | £26M |
| | Intravenous Cannula and Associated Products | London | £25M |
| | New Distribution Centre at the Port of Cardiff | Southampton | £25M |
| | Quality Funded Early Learning and Childcare (1140 Hours) | Dundee | £25M |
| | Stockport Homes Housing Management System | Stockport | £25M |
| | New Kitchens and Electrical Re-Wires | Bristol | £23M |
| | Life Systems Services 2 | Leeds | £23M |
| | Temporary River Crossing at Hammersmith Bridge | London | £22M |
| | Integrated Sexual Health Service | Stockton on Tees | £22M |
| | Medical Cylinder Gases Framework | Sheffield | £22M |
| | Janitorial and Facilities Supplies Framework Solution | Durham | £21M |