| | Digital Specialists and Programmes (DSP) | Liverpool | £4B |
| | Digital Specialists and Programmes PIN | Liverpool | £4B |
| | Integration and Design Development Partners | Didcot | £1B |
| | NHS Framework Agreement, Branded Medicines for London and South of England | Leeds | £1B |
| | Electricity and Ancillary Services | Wakefield | £1B |
| | Information Technology Commercial Framework (ITCF) | Leeds | £1B |
| | Invitation to Offer for NHS Framework for the North of England, Branded Medicines – Tranche B,… | Runcorn | £864M |
| | Engines Future Support | Yeovil | £833M |
| | Low Value Facilities Management & Workplace Services DPS | Liverpool | £500M |
| | Property Construction Partnership Framework | Maidstone | £500M |
| | NHS Framework Agreement, Branded Medicines for London and South of England | Runcorn | £442M |
| | NHS Framework for the North of England, Branded Medicines - Tranche B, Annual Tranche and Insulin… | Runcorn | £432M |
| | Facilities Management Services | Edinburgh | £400M |
| | Live at Home Framework | Chelmsford | £400M |
| | Provision Artificial Intelligence (A.I), Imaging and Radiotherapy Equipment, Associated Products and Diagnostic Imaging | Salford | £360M |
| | Agency Nurses, Midwives, Health Visitors, Healthcare Assistants and Operating Department Practitioners | Cardiff | £352M |
| | SWAN Re-Procurement | Edinburgh | £350M |
| | Lateral Flow Testing Devices for the Detection of COVID-19 Viral An | London | £325M |
| | Lateral Flow Testing Devices for the Detection of COVID-19 Viral Antigens | London | £325M |
| | Human Normal Immunoglobulin & Anti-D Immunoglobulin | Runcorn | £300M |
| | Drugs of Abuse and Point of Care Testing | Salford | £280M |
| | Lateral Flow Testing Devices for the Detection of COVID-19 Viral Antigens | London | £272M |
| | NHS National Pharmaceuticals Wave 14 CESW | Runcorn | £260M |
| | NHS National Pharmaceuticals Wave 14 LSNE | Runcorn | £260M |
| | NHS National Pharmaceuticals Wave 14 NWLN | Runcorn | £260M |
| | Work Focused Activities | London | £250M |
| | Lateral Flow Testing Devices for the Detection of COVID-19 Viral Antigens | London | £243M |
| | NHS Education With Guy's & St Thomas' NHS Foundation Trust | Leeds | £201M |
| | NHS Education With Guy's & St Thomas' NHS Foundation Trust | Leeds | £201M |
| | NHS Education With Barts Health NHS Trust | Leeds | £201M |
| | NHS Education With Barts Health NHS Trust | Leeds | £201M |
| | Building Safety Services Framework | London | £200M |
| | Passenger Lifts Maintenance & Repair Services Framework | London | £200M |
| | Fire Safety Consultancy | Bolton | £175M |
| | Fire Safety Works | Bolton | £175M |
| | Gas Servicing and Repairs | Bolton | £175M |
| | EdCity Master Development Agreement | London | £148M |
| | Primary Care ICS Training Hubs | Leeds | £135M |
| | NHS National Pharmaceuticals Wave 14 CESW | Runcorn | £130M |
| | Food and Beverage Supplies | Bolton | £125M |
| | NHS Education With King's College Hospital NHS Foundation Trust | Leeds | £123M |
| | NHS Education With King's College Hospital NHS Foundation Trust | Leeds | £123M |
| | Automated Laboratory Medicine Systems | Londonderry | £106M |
| | Vehicle Licensing and Inspection Services and a Technology System for Taxi and Private Hire Services | London | £103M |
| | Asbestos Abatement | Bolton | £100M |
| | Legionella and Water Hygiene Management | Bolton | £100M |
| | Lift Maintenance, Hoists and Servicing | Bolton | £100M |
| | Managed Stores & Materials Replenishment Solution | Castleford | £100M |
| | Office Administration Supplies | Bolton | £100M |
| | Water an Sewerage Services | West Malling | £100M |
| | Subject Knowledge Enhancement (SKE) | London | £96M |
| | Provider Panel for Day Service | Durham | £90M |
| | NHS National Pharmaceuticals Orals Plus Non Parenterals | Runcorn | £86M |
| | Shule Bora (Quality Education) | East Kilbride | £80M |
| | Integrated Urgent Care Services on Behalf of the South West London Integrated Care System | Salford | £71M |
| | Stonewater-Heating Contracts in the West and East & North Regions | Leicester | £68M |
| | Respiratory Solutions | Normanton | £61M |
| | National Framework for Centralised Prescription Hubs (Bladder and Bowel) | Chester | £60M |
| | Care at Home Services for Adults Accreditation | Nottingham | £56M |
| | Architectural Services for New Build Housing | Falkirk | £50M |
| | Commercial and Light Catering Equipment | Leicester | £50M |
| | Local Energy Consultancy Framework | London | £50M |
| | Civil Service Learning Call Off | London | £49M |
| | NHS National Pharmaceuticals Transition | Runcorn | £45M |
| | Neonatal Equipment, Adult, Paediatric & Neonatal Phototherapy Devices and Associated Accessories & Services | London | £44M |
| | Healthcare Services at Heathrow Immigration Removal Centres (IRCs) | Leeds | £41M |
| | Office and Outdoor Furniture | Wakefield | £40M |
| | Technical and Highways Works Framework | Swinton | £40M |
| | Award Notice | Newcastle upon Tyne | £35M |
| | Maintenance Tender Including Responsive Repairs & Voids, 3 Star Gas Servicing and Electrical Testing 2021 | Liverpool | £35M |
| | Engineering and Regeneration Professional Services Framework | Hull | £34M |
| | Mechanical and Plumbing (Incl. Water Safety) Consumables [3225042] | Ballymena | £33M |
| | Postal Services National Framework (Scotland) | Glasgow | £32M |
| | Application Development & Application Test | London | £32M |
| | Prevention and Early Help Services | Sale | £31M |
| | Provider List for Break Time, Day Time and Night Time Services for Children and Young People… | Preston | £31M |
| | 16+ High Support Needs Open Framework | Winchester | £30M |
| | CHIC Conveyancing Services Framework | Birmingham | £30M |
| | Civil & Structural Engineering Services for New Build Housing | Falkirk | £30M |
| | Earthworks for the Global Centre for Rail Excellence | Manchester | £30M |
| | Non-Domestic Community Waste and Recycling Collection and Disposal Services | Leicester | £30M |
| | Quantity Surveying Services for New Build Housing | Falkirk | £30M |
| | Therapeutic Support Services | Northallerton | £30M |
| | Laboratory Managed Service - Extension | Glasgow | £28M |
| | Milk, Dairy, Bread & Morning Goods | Manchester | £28M |
| | Combined Safety Syringes and Needles for the COVID-19 Vaccination Programme | London | £27M |
| | Low Carbon Development Initiative (LCDI) Phase 2 | East Kilbride | £27M |
| | Global Airline Partner Framework Agreement | London | £27M |
| | Neutral Vendor for Agency Staff | Matlock | £26M |
| | NHS Education With Barnsley Hospital NHS FT | Leeds | £25M |
| | NHS Education With Barnsley Hospital NHS FT | Leeds | £25M |
| | Domiciliary Care Service | West Midlands | £25M |
| | DUD - Carriageway Surfacing Term | Dudley | £25M |
| | Home Care Support Framework (Flexible Framework) | Bracknell | £25M |
| | Haulage and Storage (H&S) | London | £25M |
| | Tender for a UX Layer | Milton Keynes | £24M |
| | High Speed Two (HS2) Limited, Phase One Stations - For Low Voltage (LV) Power | Birmingham | £22M |
| | High Speed Two (HS2) Limited, Phase One Stations - For Low Voltage Power Components | Birmingham | £22M |
| | Electrical Equipment, Consumables, Lighting and Cable [3108330] | Ballymena | £22M |
| | Electronic Counter Measures (ECM) | London | £20M |