| | National Microbiology Framework - Lot 4: Clinical Laboratory Diagnostic Testing Services | London | £15B |
| | NHS England IC Framework — NHS Increasing Capacity Framework | Leeds | £10B |
| | Imaging, Radiotherapy and Endoscopy Equipment, Ancillary Devices and Associated Goods and Services | London | £4B |
| | Imaging, Radiotherapy, Endoscopy, Ancillary Devices and Related Goods & Services | London | £4B |
| | National Microbiology Framework - Lot 1: Diagnostic Goods and Services | London | £3B |
| | Havering Estate Regeneration Partner - Property/Asset JV Company | Romford | £1B |
| | Havering Estate Regeneration Partner – Property/Asset JV Company | Romford | £1B |
| | Medium Schemes Framework 4 (MSF4) on Behalf of Midlands Highways Alliance Plus (MHA+) | Leicester | £1B |
| | Compliance Services Framework | Birmingham | £600M |
| | Computer, Servers, Storage and Related Solutions Including Converged and HPC | Reading | £600M |
| | Risk Assessments Framework Procurement | Birmingham | £600M |
| | London Highway Maintenance and Projects Framework | London | £551M |
| | HE National Apple Equipment & Services Framework Agreement | Cardiff | £500M |
| | Property Services | London | £448M |
| | Commercial and Project Management Services | Leeds | £420M |
| | Servers Storage Solutions National Agreement | Reading | £400M |
| | iBus2 Services | London | £395M |
| | Works Construction Contractors Framework Agreement | Eastleigh | £350M |
| | Compliance Services Framework | Birmingham | £300M |
| | Modern Slavery Victim Care | London | £281M |
| | Framework for Ambulance & Specialist Vehicle Conversions | Cambridge | £250M |
| | South East Consortium New Build Framework | Surrey | £250M |
| | Concrete Roads Programme - Reconstruction Works Framework | Bedford | £218M |
| | One London Local Health and Care Record Dynamic Purchasing System | London | £200M |
| | WBC Town Hall Quarter - Development Partner Procurement | Watford | £200M |
| | ISFE Extension During Re-Procurement | Leeds | £186M |
| | Multi Project Procurement - Mechanical Pipework | Whitehaven | £176M |
| | Energy Framework Requirements April 21 | Salisbury | £140M |
| | Concrete Roads Programme - Reconstruction Works Framework | Bedford | £131M |
| | Home Care for Leicestershire | Leicester | £125M |
| | Traffic Management Service | Glasgow | £118M |
| | National Professional Qualifications Delivery Framework | London | £115M |
| | South East Wales Technical and Professional Services | Cardiff | £107M |
| | Employee Development Services | Sheffield | £100M |
| | Primary Contractor Framework 2021 - Portsmouth & Sub Region | Portsmouth | £100M |
| | Primary Contractor Framework 2021- Portsmouth & Sub Region | Hampshire | £100M |
| | Translink — Liquid Fuel for Bus and Rail | Belfast | £97M |
| | Building Maintenance & Refurbishment Services Framework | London | £95M |
| | Human Albumin | Runcorn | £70M |
| | Oxford Phase 2 Works - Botley Bridge, Platform 5, Track & Crossovers | London | £70M |
| | Concrete Roads Programme - Lifecycle Extension Works Framework | Bedford | £67M |
| | Development Partner | Newcastle upon Tyne | £60M |
| | Home Support Services Nightly Let - Temporary Accommodation | Central Milton Keynes | £60M |
| | Select List Framework for Highway Works | Lincoln | £60M |
| | Community Based Care and Support: Homecare and Outreach for Adults in the South of the Borough… | Uxbridge | £56M |
| | Community-Based Care and Support: Homecare and Outreach for Adults in the South of the Borough | Uxbridge | £56M |
| | Prison Education Dynamic Purchasing System for IAG for Residents at HMP Norfolk Prison Group | Leeds | £51M |
| | Framework for Dangerous Structures | London | £50M |
| | Recycle and Refuse Containers | Paisley | £50M |
| | Utilities Partner | Newcastle upon Tyne | £50M |
| | Acquisition of Land and Associated Construction Works Relating to Proposed Becketwell Venue, Colyear Street, Derby | Derby | £46M |
| | Neonatal Equipment, Adult, Paediatric & Neonatal Phototherapy Devices and Associated Accessories & Related Services | London | £44M |
| | Heart of the City II — Block H | Sheffield | £42M |
| | Housing-Related Floating Support | Lewes | £38M |
| | Housing Infrastructure Fund (HIF) Banwell Bypass and Highway Improvements | Weston Super Mare | £38M |
| | South West & Mid Wales Regional Civil Engineering Services | Carmarthen | £36M |
| | Amphora 2 | Bristol | £35M |
| | Centres of Expertise (4 Lots) | Glasgow | £35M |
| | West Marina Land Disposal and Development | Hastings | £35M |
| | Speech and Language Therapy Service | Norwich | £34M |
| | Maintenance of Vehicles - NHSCT [3076432] | Ballymena | £33M |
| | Residual Waste Disposal for Bournemouth and Christchurch | Bournemouth | £33M |
| | Brentford Waterside Block D Mini-Competition | Hounslow | £30M |
| | Supervised and Supported Living Accommodation for Young People in Care and Care Leavers Up to 19… | Ipswich | £30M |
| | Meridian Water Rail Project | Enfield | £28M |
| | Social Care Case Management Solutions Software | Paisley | £28M |
| | Grant Award Notice for Hardship Fund for Families of Disabled or Seriously Ill Children | Sheffield | £27M |
| | Human Albumin | Runcorn | £26M |
| | Stopped Vehicle Detection (SVD) 2020 (Lot 1) | Birmingham | £26M |
| | EUX Development | Reading | £25M |
| | Grounds Maintenance Services | Leicester | £25M |
| | Major Adaptations and Housing Assistance Works | Dudley | £24M |
| | UK Based Language Training and Examinations | London | £24M |
| | Supply & Distribution of Milk | Paisley | £24M |
| | Legal Services | Solihull | £22M |
| | Concrete Roads Programme - Lifecycle Extension Works Framework | Bedford | £22M |
| | Specialist Homecare Services on the Isle of Wight | Newport | £20M |
| | School Meals Catering Service | Morden | £20M |
| | MPU RMI UK LTD | London | £20M |
| | Cardiovascular and Respiratory Medicines | Edinburgh | £19M |
| | St Helens Borough Council an Integrated 0-19 Healthy Child Programme September | St Helens | £18M |
| | Development Partner Services | Folkestone | £18M |
| | Pharmacy Clean Room and the Related Consumables | Sheffield | £18M |
| | Strategic Implementation Partner for the Implementation of Organisational Design at BCP Council | Bournemouth | £18M |
| | Auto-Injector Partner | London | £18M |
| | Vehicle Scrappage Scheme | Birmingham | £18M |
| | Vehicle Scrappage Scheme -Concession | West Midlands | £18M |
| | National Standardised Assessments in Support of the National Improvement Framework | Glasgow | £17M |
| | Non Emergency Patient Transport Including High Dependency | Staffordshire | £17M |
| | Frozen Food | Matlock | £17M |
| | Redevelopment of the Existing YMCA Building at 200 the Broadway, Wimbledon, SW19 1RY | London | £17M |
| | Redevelopment of the Existing YMCA Building at 200 the Broadway, Wimbledon, SW19 1RY | London | £17M |
| | Supportive Medicines — Additional Products (ITU, Antibiotics and EOI Medicines) Open Supportive Medicines — Additional Products… | London | £16M |
| | Supportive Medicines - Additional Products (ITU, Antibiotics & EOI Medicines) | Reading | £16M |
| | Water System Risk Assessment and Water Hygiene | Leicester | £16M |
| | Water System Risk Assessment and Water Hygiene Monitoring | Leicester | £16M |
| | Apprenticeship DPS (Dynamic Purchasing System) | Milton Keynes | £15M |
| | Main Part Steel and Circular Hollow Material FW for Railway Overhead Line Electrification | Pontypridd | £15M |
| | Maudsley Model of Anorexia Therapy for Adults | Leeds | £15M |
| | Durham History Centre (DHC), Newbuild Extension and Refurbishment of Grade II Listed Manor House | Durham | £14M |