| | National Microbiology Framework - Lot 4 Clinical Laboratory Diagnostic Testing Services | London | £15B |
| | North Lanarkshire Council – Enterprise Strategic Commercial Partnership | Motherwell | £6B |
| | Security - Physical, Technical and Support Services | Liverpool | £3B |
| | National Microbiology Framework - Lot 3 Manufacturing, Product Development and Commercialisation | London | £2B |
| | National Microbiology Framework - Lot 3: Manufacturing, Product Development and Commercialisation | London | £2B |
| | Managed Services Solutions | Normanton | £2B |
| | Managed Services Solutions and Associated Services | London | £2B |
| | National Microbiology Framework - Lot 2: Research Goods and Services | London | £2B |
| | Voucher Schemes | Liverpool | £2B |
| | London Highway Maintenance and Projects Framework | London | £1B |
| | Back Office Software | Liverpool | £1B |
| | Digital and IT Professional Services (DIPS) Framework | Corsham | £1B |
| | Private Sector Development Partner for the West Territory | Edinburgh | £1B |
| | Apprenticeships Commissioning Programme Wales Framework Agreement | Cardiff | £1B |
| | Multifunctional Devices (MFDs), Print and Digital Workflow Software Services and Managed Print Service Provision | Liverpool | £850M |
| | Lifting Equipment & Mobility Aids Framework 2021-A | Birmingham | £800M |
| | Personal Protective Equipment and Medical Equipment | London | £573M |
| | New Velindre Cancer Centre MIM Project | Cardiff | £562M |
| | B2G Minor Works, England | Chalfont St Peter | £500M |
| | Residential Care Home Services (Learning Disability, Physical Disability & Mental Health), Supported Living Services and Care… | Maidstone | £434M |
| | Servers Storage Solutions National Agreement | Reading | £400M |
| | Asbestos Abatement Framework Procurement 2021-B | Birmingham | £300M |
| | Development Partner for the Tickford Fields Farm. Newport Pagnell | Milton Keynes | £300M |
| | Development Partner for the Tickford Fields Farm Site , Newport Pagnell | Milton Keynes | £300M |
| | South East Wales Technical and Professional Services | Cardiff | £300M |
| | Archaeology Framework | Bedford | £250M |
| | Round 2 Gloucestershire Health and Social Care Pseudo-Framework 2020 | Gloucester | £244M |
| | Probation Services Dynamic Framework (PSDF) — Day 1 Services | London | £242M |
| | NHS Framework for the Midlands and East, Branded Medicines - Tranche B | Runcorn | £228M |
| | Occupational Health, Employee Assistance Programmes and Eye Care | Liverpool | £220M |
| | Universal Credit Contact Centre Services | Leeds | £200M |
| | Cleaning & Janitorial Services at the British High Commission Islamabad & British Deputy High Commission Karachi… | London | £196M |
| | Development Contractors Framework | Liverpool | £192M |
| | Archaeology Framework | Bedford | £159M |
| | Regulated Homecare Services: For Providers in Somerset | Taunton | £155M |
| | Cambridgeshire County Council Design & Build Contractor Framework | Cambridge | £150M |
| | SLC's Technology Group Strategic Partner for Platform Delivery and Technology Services | Glasgow | £150M |
| | Round 2 Gloucestershire Health and Social Care Pseudo-Framework 2020 | Gloucester | £144M |
| | Contractor to Establish and Operate the Institute of Teaching | London | £121M |
| | Examination Gloves | Cardiff | £120M |
| | Uninterrupted Brighton Mainline Cellular Internet and Mobile Reception | London | £118M |
| | National Professional Qualifications Delivery Framework | London | £115M |
| | B2G Minor Works, English Regions | Chalfont St Peter | £100M |
| | Cambridgeshire and Peterborough Joint Professional Services Framework | Cambridge | £100M |
| | Construction Professional Services Dynamic Purchasing System | Liverpool | £100M |
| | Housing Development Framework | Sandbach | £100M |
| | Personal Protective Equipment Supply Dynamic Purchasing System | Nottingham | £100M |
| | Procurement of Cable | London | £100M |
| | Care at Home and Reablement Services | Bexleyheath | £97M |
| | DHSC International Freight and Logistics Solutions | London | £96M |
| | Supported Living Services for Individuals With a Learning Disability, Autistic Spectrum Conditions and/or Mental Health Conditions… | Stafford | £94M |
| | Civil Engineering and Infrastructure Works Framework | Sunderland | £90M |
| | Home Office Self Isolation Checks | Liverpool | £90M |
| | FSA Delivered Official Controls in England and Wales | York | £87M |
| | Domiciliary Support Service 2020 Lot 1 - General Domiciliary Support in Leicester City | Leicester | £83M |
| | DDaT Software Engineering Partner Services | London | £80M |
| | Energy Efficiency Retrofit Projects - Managing Agent | Ely | £78M |
| | Energy Efficiency Retrofit Projects – Managing Agent | Ely | £78M |
| | Housekeeping Services to the British High Commission (BHC) New Delhi, British Deputy High Commission (BDHC) Chennai,… | London | £76M |
| | Cleaning Equipment Supplies & Associated Products | Sheffield | £71M |
| | Cleaning Supplies Equipment and Associated Products | Sheffield | £71M |
| | Independent Fostering Agencies, Lot 1 — Standard Foster Placements Including Respite; Lot 2 — Parent and… | Winchester | £70M |
| | Lease Vehicles Up to 3.5 Tonnes | London | £70M |
| | IUPC Laboratory Gases and Associated Equipment Framework Agreement | Reading | £67M |
| | Modern Apprenticeships 2021-22 - Training Provider and Employer | Glasgow | £65M |
| | Fire Remedial Works | Bradford | £62M |
| | Restructuring Services, Forensic Accounting, Investigation, Audit and Assurance Framework | London | £60M |
| | Restructuring Services, Forensic Accounting, Investigation, Audit and Assurance | London | £60M |
| | Gwasanaeth Cymorth Gofal Cartref - Domiciliary Care Support Service | Carmarthen | £60M |
| | Learning Disability Open for Providers in Somerset | Taunton | £60M |
| | Variation Agreement #5 (Extension of Term of Waste Water Surveillance Testing) | London | £59M |
| | Heating Oil and Motor Fuel Framework | Hampshire | £55M |
| | Heating Oils, Motor Fuels and Biofuels | Winchester | £55M |
| | Providing Operations and Maintenance Services of Air Conditioning System (Including HVAC, Chillers, VRV’s and Split AC’s)… | London | £51M |
| | Development and Live Support of the DWP Digital Children's Platform | London | £51M |
| | Care Technology Service | Chelmsford | £50M |
| | CPCA - CAM Programme Procurements | Ely | £50M |
| | Dynamic Purchasing System (DPS) Apprenticeship Training Providers and Associated Training | Nottinghamshire | £50M |
| | Legal Services | Sheffield | £50M |
| | Offsite Volumetric Category 1 Housing Construction Framework | Chipping Sodbury | £50M |
| | Water Services Procurement DPS | Preston | £50M |
| | Traffic Scotland Systems (TSSC) | Glasgow | £47M |
| | Group Medical Insurance for Locally Engaged Staff (And Their Dependents) of British High Commission in India… | London | £46M |
| | Lower Thames Crossing - Tunnelling and Associated Works Activities (Spoil Disposal From North Portal) | Bedford | £44M |
| | Manned Security and Keyholding Services | Worcester | £41M |
| | Framework for Fully Certified Passivhaus or Passivhaus Specification (Low Energy Building) Construction Services | Dumfries | £40M |
| | Settlement Agreement | London | £38M |
| | Housing Infrastructure Fund (HIF) Banwell Bypass and Highway Improvements | Weston Super Mare | £38M |
| | Automated Blood Sciences Managed Service | St Asaph | £38M |
| | WD Portsmouth | Bristol | £37M |
| | South West and Mid Wales Regional Civil Engineering Services | Carmarthen | £36M |
| | Amphora 2 | Bristol | £35M |
| | West Marina Land Disposal and Development | Hastings | £35M |
| | Criminal Defence Direct Services in England and Wales From 1 June | London | £35M |
| | DHSC International Freight and Logistics Solutions | London | £34M |
| | Land, Design and Build Framework Ahoghill, Co Antrim | Omagh | £34M |
| | Business Support Services DPS | Warwick | £30M |
| | Catering and Corporate Hospitality Services | Coleraine | £30M |
| | Incontinence Products (Pads) Incl. A Delivery Service to Hospitals & Patient Homes - All Wales | Cardiff | £30M |
| | Medicines Management Service | Leicester | £30M |