| | Travel and Venue Solutions | Liverpool | £12B |
| | Travel and Venue Solutions | Liverpool | £5B |
| | Aseptically Prepared Dose Banded Medicines | Birmingham | £4B |
| | TfL 95052 Bollo Lane Opportunity | London | £1B |
| | PfH Framework Agreements 2021 | Warrington | £1B |
| | Prior Information Notice - Torus Repair, Maintenance and Associated Services | St Helens | £1B |
| | Property, Building and Infrastructure Advice and Management Services | Leicester | £750M |
| | Debt Resolution Services | Liverpool | £645M |
| | IT Hardware Including New, Remanufactured and Refurbished, Disposal and Associated Services | West Malling | £500M |
| | Monklands Hospital Replacement Project | Bothwell | £500M |
| | Products for the Treatment of Bleeding Disorders Including Haemophilia B | Runcorn | £500M |
| | Residual Waste Disposal Services | Hertford | £454M |
| | Books, E-Books, E-Textbooks and Associated Services | Reading | £360M |
| | Dynamic Purchasing System - Development Contractors | Manchester | £270M |
| | Diagnostic Service Solutions | Birmingham | £260M |
| | Bleeding Disorders Including Haemophilia B | Runcorn | £250M |
| | ICT Goods and Services to the Education Sector and Any UK Public Sector Body | Peterborough | £250M |
| | Property, Building and Infrastructure Advice and Management Services | Leicester | £225M |
| | National Careers Service - Community Based Contracts | London | £186M |
| | National Careers Service - Community Based Service | London | £186M |
| | Forensic Analytical Services | Carmarthen | £151M |
| | Transport for Wales Stations Modifications and Enhancements Framework | Newport | £150M |
| | Tier 3 Community Accommodation Services: Prior Information Notice | London | £143M |
| | Pharmacy Homecare Delivery Services | Birmingham | £135M |
| | Future eGates | London | £132M |
| | Winter Surge Capacity (21/22) | London | £127M |
| | Forensic Analytical Services | Carmarthen | £126M |
| | Deloitte NTP Phase 5 | London | £124M |
| | VVI Interim (Evolve) | London | £105M |
| | Artificial Intelligence Solutions | Birmingham | £100M |
| | Books, E-Books, E-Textbooks and Associated Services | Reading | £100M |
| | Employee Development Services | Sheffield | £100M |
| | NHS NOE CPC - Employee Development Services | Sheffield | £100M |
| | PfH Scotland EESSH2 Framework | Stirling | £100M |
| | Social Housing Emerging Disruptors (SHED) Framework | Warrington | £100M |
| | One HMG Movement of Personal Effects | London | £96M |
| | My Life PDSP | Wakefield | £95M |
| | Grounds Maintenance Framework - Market Engagement Opportunity | Prescot | £85M |
| | Covid-19 Support Grant - Restart: First Scotland | Glasgow | £82M |
| | Digital Partner | Nottinghamshire | £80M |
| | Legal Advisory Services | Salford Quays | £80M |
| | University of Nottingham - Digital Partner | Nottingham | £80M |
| | Hosting Capability Supplier | London | £70M |
| | Gigabit Infrastructure Subsidy Programme - Regional Supplier Cambridgeshire and Adjacent Areas | London | £69M |
| | Gigabit Infrastructure Subsidy Regional Supplier Cambridgeshire | London | £69M |
| | Covid-19 Support Grant – Restart: (Stagecoach Group) | Glasgow | £62M |
| | Cardiac Diagnostics Equipment, Technologies, and Related Equipment and Services | London | £60M |
| | Renewable Energy Assets Framework (REAF) | Huntingdon | £60M |
| | University of East Anglia Total Facilities Management | Norfolk | £60M |
| | Winter Surge Capacity (2021/22) | London | £58M |
| | Covid-19 Support Grant – Restart: (Lothian) | Glasgow | £56M |
| | Antibiotic, Antiviral & Genito Urinary Medicines | Edinburgh | £55M |
| | ETMP & EOPS Run and Associated Change Services | London | £51M |
| | Communication Solutions and Associated Telephony Services | West Malling | £50M |
| | Accommodation and Support for 16+ Older Looked After Young People and Care Leavers | Chichester | £45M |
| | Framework for Home Care Services in Herefordshire | Hereford | £45M |
| | MLS for Military Bespoke Training | Bristol | £45M |
| | Digital Transformation of Screening | Leeds | £40M |
| | PfH Decorative Solutions & Associated Services Framework | Warrington | £40M |
| | South Wales Trunk Road Agent (SWTRA) – Surfacing and Ancillary Works Framework | Port Talbot | £40M |
| | Insulin Pumps, Continuous Glucose Monitoring, Closed Loop Insulin Delivery Systems and Associated Products | London | £36M |
| | Sports Clothing | Nottingham | £32M |
| | Equipment, Installation and Maintenance Services for Urban Traffic Control Systems | Preston | £30M |
| | Open Framework for Children's and Young People's Complex Domiciliary Care Services | Winchester | £30M |
| | Multi-Disciplinary Consultancy Services (MDC1) - CPC and London & SE | Uxbridge | £23M |
| | Irvine Housing Association Repairs and Maintenance | Irvine | £21M |
| | Improving Access to Psychological Therapies (IAPT) Services in Sunderland | Sunderland | £20M |
| | Equipment, Installation and Maintenance Services for Urban Traffic Control Systems | Preston | £20M |
| | PfH Decorative Solutions & Associated Services Framework | Warrington | £20M |
| | Oracle Test Supply Chain (Build + Test + Support) | London | £18M |
| | Kincardine Bridge Southern Piled Viaduct Replacement | Glasgow | £16M |
| | Covid-19 Support Grant – Restart: (McGills) | Glasgow | £15M |
| | Adult Domiciliary(home Based) Care Services_ DPS | Maidenhead | £15M |
| | ESCC JC Translation and Interpreting Framework | East Sussex | £15M |
| | Insulin Pumps, Continuous Glucose Monitoring, Closed Loop Insulin Delivery Systems and Associated Products | London | £15M |
| | Covid-19 Support Grant – Restart: (CityLink) | Glasgow | £14M |
| | Cleaning & General Services | Uxbridge | £14M |
| | DHSC Assisted Testing RTS Call- Off Lot 3 | London | £13M |
| | Community Physiotherapy Service in Croydon to Support Integrated MSK | London | £12M |
| | HR Resourcing RFFP | Didcot | £12M |
| | Temporary and Permanent Staff to Leeds City Council | Leeds | £11M |
| | Fsast - High G Training and Test Capability | Bristol | £11M |
| | Soft Facilities Management | Coventry | £11M |
| | SDF Lot 6 North West_ Premier Roadmarkings Limited B | Birmingham | £11M |
| | Highways Planned Carriageway Maintenance Framework | Nottingham | £10M |
| | Optivo Commercial Cleaning Services | Croydon | £10M |
| | AMRAAM Systems in Service Support | Bristol | £10M |
| | HM Land Registry Technology Capability Partner (RM1043.7) | Plymouth | £9M |
| | Sudan Independent Monitoring Programme | East Kilbride | £9M |
| | Purford Green Construction Contractor | Chelmsford | £8M |
| | Covid-19 Support Grant – Restart: (West Coast Motors and Borders Buses) | Glasgow | £8M |
| | Fountain Hill Antrim | Belfast | £8M |
| | Managed Learning Service | Seascale | £8M |
| | NHSCT Framework for Minor Works | Antrim | £8M |
| | Irvine Housing Gas Servicing & Maintenance | Irvine | £7M |
| | DfE Sign In | Coventry | £7M |
| | National Professional Qualifications (NPQ) External Moderator | London | £7M |
| | National Professional Qualifications (NPQ) External Moderator- CF | London | £7M |
| | Disposal of Green, Wood, Food and BIOK Waste | London | £7M |
| | EXTRACARE CHARITABLE TRUST - Contracts for Soft Facility Management | Coventry | £7M |