| | Imaging, Radiotherapy, Endoscopy, Ancillary Devices and Related Goods and Services | Leeds | £4B |
| | Imaging, Radiotherapy, Endoscopy, Ancillary Devices and Related Goods and Services | London | £4B |
| | Technology Products and Associated Services | Liverpool | £2B |
| | NHS Branded Medicines Framework for North of England and Midlands and East of England - 1… | Leeds | £2B |
| | Postal Services and Solutions | Liverpool | £2B |
| | NHS Branded Medicines Framework for North of England and Midlands and East - 1 March | Runcorn | £910M |
| | On-Site Surgical and Medical Capacity Solutions | Chester | £816M |
| | South East Consortium Internal & External Works Framework | Surrey | £750M |
| | NHS for Aseptically Prepared Cytotoxic Medicines and Monoclonal Antibodies for the Treatment of Cancer (Lots 1,… | Leeds | £624M |
| | Digital Services Framework Agreement | London | £562M |
| | Greater Manchester Bus Franchising - Passport Process Tranches 2 and 3 | Manchester | £554M |
| | Oldham Town Centre - Master Developer Private Sector Partner (PSP) | Oldham | £550M |
| | Critical Incident Management and Public Safety Software and Systems | Wakefield | £500M |
| | DHSC Mental Health Act Culturally Appropriate Advocacy Phase II Pilots | London | £500M |
| | Plant Machinery, Grounds Maintenance and Site Equipment and Handheld Tools | West Malling | £500M |
| | Electrical Repairs, Maintenance & Installation Framework | Alfreton | £300M |
| | Overseas Deployable Food (DFP) | Bristol | £250M |
| | Overseas Deployable Food (ODF) | Bristol | £250M |
| | Passive Fire Safety Framework - Scotland & Northern Ireland | Newcastle upon Tyne | £250M |
| | Pathology Service Joint Venture | Manchester | £240M |
| | Operating Theatres Equipment and Related Accessories and Services | London | £227M |
| | Liquid Fuels | Wakefield | £200M |
| | Orthotic Products and Services (Including Prosthetic Services) | Hemel Hempstead Hertfordshire | £200M |
| | Sustainable Hardware, Asset Recycling and Data Destruction | Wakefield | £200M |
| | Procedure Packs | London | £159M |
| | National for Legacy Information Integration and Management | Chester | £150M |
| | Pulse Oximetry, Capnography and Related Patient Monitoring Technologies | London | £145M |
| | A66 North Trans-Pennine Earthworks | London | £142M |
| | Eculizumab - 1 Feb | Leeds | £122M |
| | A66 North Trans-Pennine Pavement Construction | London | £116M |
| | Contract Award | Gateshead | £110M |
| | Planned and Responsive Maintenance and Minor Works - Armagh M&E Lot 2 | Belfast | £103M |
| | Orthotic Products and Services (Including Prosthetic Services) | Hemel Hempstead | £100M |
| | Pathology Service Joint Venture | Manchester | £100M |
| | Technical System Integration Delivery Partner | London | £86M |
| | Firmus Energy Construction and Maintenance Works and Services | Antrim | £85M |
| | Media Buying | Edinburgh | £85M |
| | CHIC Agency - Dynamic Purchasing System [DPS] | Birmingham | £80M |
| | Software and Hardware Value Added Reseller | Newport | £80M |
| | UK_2022_Professional Services Business Process Outsourcing | London | £78M |
| | Prisoner Education Services (Careers Information, Advice and Guidance (CIAG)) | London | £72M |
| | Buckinghamshire Highways Framework One - Highways Minor Works | Aylesbury | £70M |
| | Instrumentation | Glasgow | £70M |
| | Wiley Jisc Read and Publish Open Access 2024 | Bristol | £66M |
| | Access & Insulation Services 2024 | Oldbury | £65M |
| | Standard Home Care (Domiciliary Care) Services | Derby | £63M |
| | Supported Living Services | Barking | £60M |
| | IT Hardware, Networking & Security Equipment and Commerical Off the Shelf Software (COTS) | Leeds | £60M |
| | IT Hardware, Networking & Security Equipment and Cots Software for Yorkshire and the Humber Police Forces… | Leeds | £60M |
| | Warehousing, Storage and Delivery Services | London | £57M |
| | Transport Services for Vulnerable Children and Adults (DPS) - ASCHIW/2022/316* | Stoke on Trent | £57M |
| | Fruit and Vegetables & Misc. Chilled Foods | Oldham | £52M |
| | Media Planning, Buying and Associated Services | Glasgow | £52M |
| | North East Lincolnshire Capital Works Framework | North East Lincolnshire | £50M |
| | Buckinghamshire Highways Framework Two - Highways Major Works | Aylesbury | £50M |
| | National Framework for Police Constable Entry Route Programmes | London | £50M |
| | North East Lincolnshire Capital Works Framework | Grimsby | £50M |
| | Optimisation | Liverpool | £50M |
| | Reactive and Responsive Maintenance and Voids | Canterbury | £50M |
| | Reactive and Responsive Repairs and Maintenance and Voids | Canterbury | £50M |
| | Replacement Mobilising System | London | £49M |
| | Redevelopment/Repurposing and Leasing of a Site in George Street, Oxford | Oxford | £49M |
| | Eculizumab - 1 Feb | Runcorn | £47M |
| | Planned and Responsive Maintenance and Minor Works - Belfast Building Lot 1 | Belfast | £46M |
| | Planned and Responsive Maintenance and Minor Works - Belfast Building Lot 2 | Belfast | £46M |
| | Care for 'Adult Rapidly Deteriorating Patients and With a Primary Health Need' Service | Basildon | £46M |
| | Generation 5 Technical Resources Framework 2024 | Hampshire | £45M |
| | Generation Five Technical Resources Framework (TRF5) 2024 | Winchester | £45M |
| | Children and Young People Including Those With Special Educational Needs and Disabilities (SEND) - DPS -… | Stoke on Trent | £44M |
| | T-MCLH - VIP Lounges Concession 2 Lots Aspire Unit and Unit 3 | Bedfordshire | £43M |
| | A66 North Trans-Pennine Steel Structures | London | £42M |
| | London Victims and Witness Service - Central Referral Mechanism and Universal Support for Adult Victims of… | Southwark | £42M |
| | Sludge Management Services | Belfast | £41M |
| | Parking Enforcement and Associated Services (Collaborative) | Sale | £40M |
| | Sehsct Framework for Building Maintenance and Building Minor Works (TSSC) | Belfast | £40M |
| | Planned and Responsive Maintenance and Minor Works - Belfast Electrical Lot 1 | Belfast | £39M |
| | Planned and Responsive Maintenance and Minor Works - Belfast Electrical Lot 2 | Belfast | £39M |
| | Planned and Responsive Maintenance and Minor Works, Armagh Building Lot 1 | Belfast | £38M |
| | Patient Monitoring, Anaesthetic Machines, Ventilators & ECG Machines | Edinburgh | £36M |
| | Step Down Beds Framework - NHS Bedfordshire, Luton and Milton Keynes ICB | Luton | £36M |
| | COV - Transport and Infrastructure Research (R&D) Partner | Coventry | £35M |
| | Transport and Infrastructure Research (R&D) Partner | Coventry | £35M |
| | Major Adaptation Construction Works to Properties for People With Disability for the Northern Ireland Housing Executive… | Belfast | £35M |
| | A66 Enterprise Project - Traffic Management Package of Works | London | £34M |
| | Planned and Responsive Maintenance and Minor Works - Dundonald Building Lot 1 | Belfast | £33M |
| | TC473 - Supply of Gas | Manchester | £32M |
| | Standard Home Care Services | Derby | £32M |
| | Term Carriageway Resurfacing (HDG/2023/603*) | Stoke on Trent | £31M |
| | Planned and Responsive Maintenance and Minor Works - Ballymena M&E Lot 1 | Belfast | £31M |
| | Construction of Falkland Islands Remote Radar Head Accommodation Replacement | Lichfield | £30M |
| | HE Framework for Supply, Installation and Management of Data Centre Management Equipment and Infrastructure | Leeds | £30M |
| | Minor Civil Works for Level Crossings and Minor Signalling Assets & Equipment Framework | London | £30M |
| | Planned and Responsive Maintenance and Minor Works - Ballymena M&E Lot 2 | Belfast | £30M |
| | Recyclates and General Waste Management | Edinburgh | £30M |
| | Planned and Responsive Maintenance and Minor Works - Omagh M&E Lot 1 | Belfast | £29M |
| | Grounds Maintenance | Belfast | £29M |
| | Appointment of A Main Contractor for Integrated College, Dungannon | Dungannon | £28M |
| | Citizen Facing Contact Centre Services | Leeds | £28M |
| | Planned and Responsive Maintenance and Minor Works, Armagh Building Lot 2 | Belfast | £28M |
| | Planned and Responsive Maintenance and Minor Works - Omagh M&E Lot 2 | Belfast | £26M |